Comparison of cardiovascular structure and function in physical active subjects with or without myocardial infarction

Comparison of cardiovascular structure and function in physical active subjects with or without myocardial infarction - Myocardial infarction and physical activity

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37343

Enrollment

Registered

2012-04-10

Start date

2012-04-18

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart attack Myocardial infarction

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Informed consent Men and women aged 40-70 years For active groups, regular physical active (i.e. aerobic exercise such as running >=3 times a week), for at least 20 years For MI groups, myocardial infarction within the past 5 years

Exclusion criteria

Exclusion criteria: Smokers Type I or II diabetes mellitus Other diseases that interfere with exercise testing For subject in non-MI groups: - hypercholesterolemia - hypertension

Design outcomes

Primary

Measure	Time frame
Vascular structure and function (conduit artery endothelial function, conduit artery diameter, blood flow, IMT, conduit and resistance artery structure, peak hypereamic blood flow, exercise-induced vasodilation) Plaque vulnerability by ultrasoiund and serum biomarkers (hs-CRP, SAA, IL-6, MMP-9, MMP-2, TIMP-1, TIMP-2) Cardiac structure and function (cardiac mass and dimensions, systolic and diastolic function parameters, left and right ventricle strain rate)	—

Measure

Time frame

Vascular structure and function (conduit artery endothelial function, conduit artery diameter, blood flow, IMT, conduit and resistance artery structure, peak hypereamic blood flow, exercise-induced vasodilation) Plaque vulnerability by ultrasoiund and serum biomarkers (hs-CRP, SAA, IL-6, MMP-9, MMP-2, TIMP-1, TIMP-2) Cardiac structure and function (cardiac mass and dimensions, systolic and diastolic function parameters, left and right ventricle strain rate)

—

Secondary

Measure	Time frame
Secondary objectives include groups comparisons of physical fitness and traditional risk factors, i.e. cholesterol, lipid profile, HbA1C, insulin sensitivity, blood pressure, and waist circumference. Two extra blood samples will be drawn and stored for future analyses (if no objection participant), in case relevant CVD genetic candidates become available.	—

Countries

Netherlands

Outcome results