preventie van hart-en vaatziekten vitamin K deficiency vitamin K insufficiency
Conditions
Interventions
During the 6-wk intervention period, the subjects will be instructed to report
any signs of illness, medication used, and any deviations from the study
protocol. Subjects will be urged not to change
therefore body weight will be measured
at the first and last study visit. In addition, two weeks (14 days) before the
start of the study until the final blood sampling, participants will be asked
t
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Apparently healthy men and postmenopausal women between 45 and 65 years old Subjects with body weight and height according to BMI between 23 and 30 kg/m2 Subject has given written consent to take part in the study Subjects of Caucasian race
Exclusion criteria
Exclusion criteria: Subjects with hypertension Subjects with hypercholesterolemia Subjects with (a history of) metabolic or gastrointestinal disease Subjects presenting chronic degenerative and/or inflammatory disease Subjects with (a history) of diabetes mellitus Abuse of drugs and/or alcohol Subjects receiving corticosteroid treatment Subjects using oral anticoagulants and subjects with clotting disorders Subjects using blood pressure-lowering medication Subjects using cholesterol-lowering medication Subjects using multivitamins or vitamin K supplements Subjects consuming high amounts of vitamin K-containing food products Subjects with cow*s milk allergy and lactose intolerance
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The biochemical markers carboxylated MGP (cMGP), desphospho-uncarboxylated MGP (dp-ucMGP), carboxylated osteocalcin (cOC) and uncarboxylated osteocalcin (ucOC), will be measured at the various time-points (t = 0, 4, 6, 7 and 8 weeks) to determine the efficacy of the nutrient-enriched product vs. the other 2 products on MGP carboxylation status in the vessel wall and OC carboxylation. | — |
Primary
| Measure | Time frame |
|---|---|
| The circulating MK-7 levels will be measured at the various time-points (t = 0, 2, 4, 6 weeks) during intervention and the wash-out period (t= 3 days, 1 and 2 weeks) to determine the absorption profile of MK-7 within the dairy product. | — |
Countries
Netherlands
Outcome results
None listed