menstruation pain/period pains
Conditions
Interventions
During a PET scan, participants will watch a video of a physician communicating
in an empathic and positive way or watching a video of a physician
communicating in an non-empathic way voicing uncert
Sponsors
NIVEL
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Women between 18 and 45 years of age, who have experienced sufficient menstrual pain (>=40% of maximum imaginable pain on a VAS intensity of pain scale) within the last six months. Have regular menstrual cycles Highest empathic scores from the screening and recruitment process (i.e. in highest tertile)
Exclusion criteria
Exclusion criteria: Inability to have an unaided conversation in Dutch Any neurological disorder Claustrophobia Metal objects in or around the body (braces, pacemaker, metal fragments) Pregnancy, or possibility that the volunteer could be pregnant Any earlier exposure to radiation in a study as a healthy volunteer leading to cumulative dose of 10 mSv or more. Pharmacological treatment with dopamine antagonists Smokers (exclusion from the PET scan section)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main outcome parameter is the change in binding potential of [11C]-raclopride in the nucleus accumbens (NAC) as an indication of endogenous dopamine release. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters are affective (state anxiety, positive and negative affect states), cognitive (outcome expectations, illness perceptions) and physiological responses (skin conductance, heart rate). | — |
Countries
Netherlands
Outcome results
None listed