aggression antisocial behavior
Conditions
Interventions
There will be oxytocin 32IU administered or normal saline, using a nasal spray.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: males between the ages of 18 and 35 years, in good health, and able to understand the informed consent as assessed by the study physician.
Exclusion criteria
Exclusion criteria: No mental disorder, current or past history of drug or alcohol abuse or dependence, history of hypersensitivity to oxytocin, presence of or history of clinically significant allergic rhinitis, smoke more than 10 cigarettes per day. Subjects will be excluded when they cannot understand the Dutch language sufficiently to understand the purposes and implications of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures will be: 1) points scored on the PSAP (oxytocin vs placebo) 2) points scored on the Trust Game (oxytocin vs placebo) 3) salivary levels in testosterone and cortisol 4) urinary and serum levels of oxytocin | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome measures on the different questionnaires: 1) Personality, as measured on the *Neuroticism-Extroversion-Openness Inventory- Five Factor Inventory* (NEO-FFI). 2) traits of psychopathy, as measured on the *Triarchic - Psychopathy Measure* (TriPM). 3) attachment styles, as measured on the *Relationship Questionnaire* (RQ) and the 'Experiences in Close Relationships' vragenlijst (ECR) 4) trust, as measured on the *Trust Inventory* (TI) 5) aggression as measuren on the "agressie vragenlijst" (AVL) 6) Mood state, measured on 2 moments during the experiment, measured on the *Profile Of Mood States* (POMS). | — |
Countries
Netherlands
Outcome results
None listed