chronic demyelinating inflammatory polyradiculoneuropathy (CIDP) no lay term
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group 1 - Adult patients (> 18 years) - Fulfilment of the EFNS/PNS criteria for probable or definite CIDP - Clinical sensory deficit corresponding with sural nerve in one or both legs AND absent sensory nerve action potential (SNAP) on nerve conduction studies. Group 2 - Adult patients (> 18 years) - Fulfilment of the EFNS/PNS criteria for probable or definite CIDP - Patients with intravenous immunoglobulin (IVIg) maintenance treatment who are eligible for IVIg withdrawal to confirm IVIg dependency - No fluctuation of clinical condition or dose of IVIg in the last 3 months
Exclusion criteria
Exclusion criteria: - Other diseases known to cause neuropathy - Use of drugs which are known to cause neuropathy - Use of immunomodulatory drugs in the last 3 months - Refusal to give informed consent or withdrawal of previously given permission - Legally incompetent adult
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Frequency and overlap of expanded T-cell clones in sural nerve biopsies and peripheral blood in patients with active disease (Group 1). 2) Change in frequency of expanded clones in blood a) comparing active disease with stable disease (Group 1) b) comparing stable disease during IVIg maintenance treatment and active disease after stopping treatment (Group 2). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. MRC sum score 2. INCAT sensory sum score 3. INCAT disability scale 4. Sural nerve biopsy questionnaire (applicable only for Group 1) | — |
Countries
Netherlands
Outcome results
None listed