Morphological and functional changes of the median nerve after neurolysis for carpal tunnel syndrome

Morphological and functional changes of the median nerve after neurolysis for carpal tunnel syndrome - ultrasonography of the median nerve after neurolysis for CTS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37253

Enrollment

100

Registered

2012-06-25

Start date

2012-11-22

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carpal tunnel syndrome median nerve neuropathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Age > 18 years 2. Clinical signs of carpal tunnel syndrome, as described by the AAN criteria for CTS: paresthesias, pain, swelling, weakness, or clumsiness of the hand (digit 1-4) provoked or worsened by sleep, sustained hand or arm position, or repetitive action of the hand or wrist that is mitigated by changing posture or by shaking of the hand; sensory deficits in the median innervated region of the hand; and motor deficit or hypotrophy of the median innervated thenar muscles 3. Electrophysiological evidence of CTS (see below) 4. Surgery is the preferred treatment modality 5. Patients having bilateral CTS can only participate with the most affected side. 6. Criterium for the time interval between initial exam and surgery: within 5 weeks 7. Able to read and understand written questionnaires (in Dutch) 8. Informed written consent

Exclusion criteria

Exclusion criteria: 1. Unable to follow up 2. Prior surgery or trauma on the wrist / median nerve 3. Previous surgery for carpal tunnel syndrome; previous surgery for CTS on the contralaterale side is not an exclusion criterium. 4. Treatment with splints or corticosteroids the past 6 months. 5. Clinical or electrophysiological evidence of conditions that could mimic CTS or interfere with its validation (cervical radiculopathy, brachial plexopathy, thoracic outlet syndrome, pronator teres syndrome, ulnar neuropathy, polyneuropathy, Raynaud*s disease, sympathic dystrophy) 6. Underlying causes of CTS: diabetes, thyroid disease, rheumatoid arthritis, chronic renal failure treated by hemodialysis, space-occupying lesions a the volar wrist. A bifid median nerve of persistant median artery are no exclusion criteria. 7. Pregnancy

Design outcomes

Primary

Measure	Time frame
Primary outcome measures 1. Change in intraneural vascularisation after neurolysis 2. Change in cross sectional area of the median nerve after neurolysis 3. Change in swelling and flattening ratio of the median nerve after neurolysis	—

Secondary

Measure	Time frame
Correlation of ultrasonographic changes and clinical/nerve conduction changes after neurolysis.	—

Countries

Netherlands

Outcome results