Autoimmuunziekten Infectious diseases and autoimmune diseases
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy volunteers (n=500): - older than 18 years - no chronic or acute disease at the time of assessment - no use of chronic or acute medication at the time of the study Inclusion criteria for the patient groups:;RVVC patients (n=200) - healthy women, age >18 years - no pregnancy, no diabetes, no antibiotic use - at least 3 episodes of vulvo-vaginal candidiasis per year, microbiologically confirmed;Candidemia patients (n=50) - patient with blood culture positive for a Candida species - age > 18 years - treatment given no longer than 24h before sample collection;Lyme disease patients (n=150) - age > 18 years old - clinical diagnosis based on erythema migrans. - positive serology (IgG) for Borrelia. ;Gout patients (n=200) - age > 18 years - diagnosis based on clinical criteria and positive urate crystals in the joint fluid;HIV-infected patients (n=400) - age > 18 years - HIV infection based on viral loads and CD4 counts - no opportunistic infection at the time of sampling
Exclusion criteria
Exclusion criteria: Pregancy Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metadata: Lifestyle questionnaires DNA: Gene polymorphisms at DNA level Microbiome: Presence of groups of bacteria Phenotype: Specific populations of cells Functional data: Cytokine production | — |
Secondary
| Measure | Time frame |
|---|---|
| Niet van toepassing | — |
Countries
Netherlands
Outcome results
None listed