side effect
Conditions
Interventions
None listed
Sponsors
Tergooiziekenhuizen Hilversum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 70 years and older - Admission on the department of Orthopedics or Surgery for hip fracture or other fall-related-fractures - Exclusion within 24 hours after admission on the department - The patient or representative speaks either Dutch or English - Patient or representative must be able to give informed consent
Exclusion criteria
Exclusion criteria: - Use of an antipsychotic agent within 90 days before hospital admission - Start or dose changes in anticoagulant drugs, drugs related to QTc-prolongation, antidiabetic, antihypertensive or cholesterol lowering drugs in the 14 days before admission Additional for subgroup 1: - History of a pacemaker implantation, atrial fibrillation, bundle branch block, congenital Qt- syndrome - Use of QT prolongating drugs (Cert list 1 www.azcert.org) in the 14 days before admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a. Serum level of fastening glucose (mmol/l). b. QTc-prolongation measured by (holter) ECG using Fridericia*s formula . | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Serum level of triglycerides (mmol/l). 2. Closure time (sec), measured by Platelet Functional Analyser (PFA-100). 3. Serum concentration haloperidol (*g/L). 4. Daily defined dose, total antipsychotic exposure in haloperidol users. 5. Genetic polymorphisms at D2 receptor, serotonin 2c receptor, methylenetetrahydrofolate reductase (MTHFR), NUBPL and NOS1AP genes. | — |
Countries
Netherlands
Outcome results
None listed