gezonde mond, tandvleesontsteking Healthy oral cavity
Conditions
Interventions
None listed
Sponsors
ACTA Dental Research B.V. (ADR)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Young individuals, * 18 years - 30 year - Male and female - Classified as systemically healthy, assessed by medical questionnaire - Minimum of 20 natural teeth: all first molars and second and/or third molars in the upper jaw available - Agree to present without eating and drinking on the morning of the appointment - Having visited the dentist for a regular check-up within the last year necessary treatment included - Willing and able to give written informed consent - Willing to consent to use the collected body materials anonymous and coded - Willing to refrain from brushing 24 hours before the morning appointment.
Exclusion criteria
Exclusion criteria: - Anyone presenting a probing depth * 5mm with bleeding on probing and attachment loss * 2 mm, Dutch Periodontal Screening Index score 3+/ 4 - Overt dental caries - No interproximal restorations between the first and second or third and second upper molars - Smokers, definition smoker: * 1 cigarette every day - Removable partial dentures - Removable night guard - Oral and/or peri-oral piercings - Ongoing dental treatment or any other medical treatment of the oral cavity - Presence of orthodontic banding (except for lingual retention wire) - Abuse of drugs/ alcohol - Dental student or dental professional - Participation in a clinical study within the previous 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primaire study parameter is the level of gingival inflammation (Bleeding On Marginal Probing (BOMP) and Bleeding upon Pocket Probing (BPP)). | — |
Secondary
| Measure | Time frame |
|---|---|
| In total there are 20 secondairy study parameters: 1. Subjective oral health 2. Generic health-related quality of life 3. Oral health-related quality of life 4. General level of nutrition measured by the Validated Food Frequency questionnaire: a. Frequency of food intake b. Macronutrients c. Micronutrients d. Sugar intake e. Soft drinks f. Energy drinks g. Juices 5. Systolic and diastolic blood pressure 6. Pulse 7. Body temperature 8. Body Mass Index a. Standing height b. Body weight 9. Abdominal (Waist) circumference 10. Blood cell parameters a. White blood cells b. Red blood cells 11. Blood biochemical parameters a. Cholesterol level in blood b. Glucose level in blood 12. Oral PMN numbers and function in comparison with systemic PMN a. Count number PMN: in saliva and in blood b. Determine functionality of PMN: from saliva and from blood 13. Saliva a. Flow rate b. pH measurement saliva c. Salivary proteome d. Microbiological composition e. Metabolite analyses 14. Plaque samples a. Metabolic activity of the dental plaque from the vestibular aspect of the upper jaw b. Microbial and micobial composition of dental plaque from the lingual aspect of the lower jaw c. Microbial and micobial composition of the interproximal plaque d. Microbial and micobial composition of the subgingival plaque. e. Metagenomic profiles of plaque samples 15. Microbial and micobial ecology tongue dorsum a. Anterior part of dorsum tongue b. Posterior part of dorsum tongue 16. Level of calculus formation at lower front teeth a. Calculus Volpe-Manhold index 17. Level of dental plaque a. Modified Silness & Löe plaque index 18. Dental caries experience a. Decayed, missed, filled teeth (DMFS) b. International Caries Assessment and Detection System (ICDAS) c. Dentinal occlusal and approximal caries 19. Oral malodour a. Organoleptic score 20. Volatile Sulphur Compounds (VSC*s) a. OralChroma outcome b. Halimeter outcome 21. Extent of tongue coa | — |
Countries
Netherlands
Outcome results
None listed