Attention-dependent modulation of TMS-evoked EEG potentials in early visual cortex

Attention-dependent modulation of TMS-evoked EEG potentials in early visual cortex - Attention-dependency of TMS-evoked potentials

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37221

Enrollment

Registered

2012-10-16

Start date

2013-03-02

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nvt na

Interventions

Participants will receive 800 trials of single-pulse TMS of the early visual cortex at 80% individual phosphene threshold.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Only healthy, competent, right-handed participants, 18*45 years old, with normal vision or corrected-to normal vision by means of contact lenses, able to consistently perceive phosphenes evoked by single-pulse TMS of the visual cortex will be recruited.

Exclusion criteria

Exclusion criteria: - Epilepsy, convulsion or seizure - Serious head trauma or brain surgery - Large or ferromagnetic metal parts in the head (except for a dental wire) - Implanted cardiac pacemaker or neurostimulator - Pregnancy - Large of ferromagnetic metal parts in the body - Claustrophobia - Skin diseases at intended electrode sites - Disorders of vision (i.e., deviation from *normal or corrected-to-normal vision*) - History or current presence of any neurologic or psychiatric disease - Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation

Design outcomes

Primary

Measure	Time frame
To study the relationship between TMS-evoked and spontaneous alpha oscillations. We expect TMS-evoked and spontaneous alpha oscillations to respond similarly to changing levels of visual attention. More specifically, we expect attention to the visual stream to result in a decrease of both the amplitude and power of spontaneous as well as TMS-evoked alpha oscillations, whereas attention to the auditory stream should result in an increase of both. We further expect that individual frequency and amplitude of TMS-evoked and spontaneous oscillations correlate across subjects.	—

Measure

Time frame

To study the relationship between TMS-evoked and spontaneous alpha oscillations. We expect TMS-evoked and spontaneous alpha oscillations to respond similarly to changing levels of visual attention. More specifically, we expect attention to the visual stream to result in a decrease of both the amplitude and power of spontaneous as well as TMS-evoked alpha oscillations, whereas attention to the auditory stream should result in an increase of both. We further expect that individual frequency and amplitude of TMS-evoked and spontaneous oscillations correlate across subjects.

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Secondary

Measure	Time frame
To investigate the feasibility of transcranially inducing specific brain oscillations in order to establish a causal link between neuronal oscillations and cognition. Starting out from single-pulse TMS-evoked oscillations we hope to also improve the understanding of how frequency-specific repeated perturbations (i.e., repetitive TMS) can be used to modulate spontaneous brain oscillations in health and disease.	—

Measure

Time frame

To investigate the feasibility of transcranially inducing specific brain oscillations in order to establish a causal link between neuronal oscillations and cognition. Starting out from single-pulse TMS-evoked oscillations we hope to also improve the understanding of how frequency-specific repeated perturbations (i.e., repetitive TMS) can be used to modulate spontaneous brain oscillations in health and disease.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)