Familial Gastric Cancer
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1] Adult from age of 18 years, female and male relatives 2] Fully legal competent (to simplify the common consent agreement for blood withdrawal, and serial endoscopies.) 3] Individuals that signed the common consent agreement 4] First degree relative of an individual with diffuse gastric cancer from a Familial Gastric Cancer-family: o OR: 2 or more individuals with diffuse gastric carcinoma, at least one
Exclusion criteria
Exclusion criteria: - immature individuals - actual gastric ulcer or gastric bleeding - previous diagnosis of cancer - individuals with co-morbidity which might increase the sedation and/or endoscopy risk: COPD Gold III/IV Cardiac failure Increased bleeding tendency or use of medication which increases bleeding tendency (and cannot be stopped temporarily)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study outcome of this study is to determine if spraying of the gastric mucosa with acetic acid and Indigo carmine will increase the detection rate of these (pre)malignant lesions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study paramers of this study are: A] To determine if standardized sampling, colouring and examination of the histological specimens will contribute to the detection of (pre-)malignant FDGC. B] To determine the optimal interval for endoscopic screening. C] To determine the contribution as well as association with clinical, life-style and dietary habits to the development of FGC. D] And finally, to determine the psychosocial impact of screening in individuals in this population. | — |
Countries
Netherlands
Outcome results
None listed