contrast-induced nephropathy/ kidney damage after contrast administration
Conditions
Interventions
Arm A: sodium chloride 1g/10kg of body weight /day per os on day -2 and -1
before contrast exposure. (maximum of 10 gram per day in case of obesitas)
Arm B (standard procedure): Nacl 0.9% total 1000m
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients >18 years undergoing an elective procedure involving intravascular administration of iodinated contrast media and at high risk for the development of Contrast Induced Nephropathy (as defined by guideline criteria). High Risk (HR) eGFR= 2 risk factors: - Peripheral Arterial Disease - Heart Failure - Age >75 yrs - Anemia (Ht 150ml - Cardiological intervention eGFR
Exclusion criteria
Exclusion criteria: Age 25% change
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be the ratio between the 48-72 hours creatinine levels and the baseline levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, we will evaluate the incidence of contrast nephropathy in the groups Defined as a rise in serum creatinine of >=25% or >=44umol/L 48-72 hours after contrast administration. Finally, the incidence of adverse event will be evaluated. And patient satisfaction. | — |
Countries
Netherlands
Outcome results
None listed