chronic depression major depressive disorder (chronic)
Conditions
Interventions
Mindfulness based cognitive therapy (MBCT) compared with treatment as usual.
Sponsors
Pro Persona (lokaties Nijmegen, Arnhem, Ede en Tiel)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with a major depressive disorder (according to DSM-IV) with a duration of one year or longer. Patients have responded insufficiently (IDS >21, moderate depression) to a therapeutic dose of antidepressant medication and a psychotherapy protocol (cognitive behavioral therapy or interpersonal psychotherapy).
Exclusion criteria
Exclusion criteria: Bipolar disorder Any primary psychotic disorder Clinically relevant neurological or other somatic illness Current alcohol or drug misuse Use of high dosage of benzodiazepines (>2 mg lorazepam equivalents daily) Recent Electro Convulsive Therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will consist of a reduction in depressive symptoms according to the Inventory of Depression symptomatology (IDS-SR, Rush, Gullion, Base et al, 1996). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include: rumination (Ruminative Response Scale and Rumination on Sadness Scale (Raes et al, 2003), mindfulness skills (Five Facet Mindfulness Questionnaire, Baer et al, 2006), self-compassion (Self Compassion Scale; Neff, 2003) and quality of life (QOL WHO, World health Organization, 2004) and general health (EQ-5D; Dolan et al, 1997). | — |
Countries
Netherlands
Outcome results
None listed