knee osteoarthritis knee wear
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient is older than 18 years, knee pain for more than one month, a discrepancy in radiological OA stage between both compartments of the tibiofemoral joint (one compartment severe and one compartment mild to moderate OA according to Kellgren & Lawrence, and one of the following: patient is older than 38 years, there is less than 30 minutes of morning stiffness in the knee or crepitures and bony enlargement are present during physical examination.
Exclusion criteria
Exclusion criteria: Severe knee OA without asymmetric distribution in severity between both compartments of the tibiofemoral joint, varus or valgus deformity in the knee > 10 degrees, chondrocalcinosis, absolute and relative contra-indications to undergo MRI: brain aneurysm clip, implanted neural stimulator, cardiac pacemaker or defibrillator, cochlear implant, ocular foreign body, other implanted medical devices: (e.g. catheters, insulin pump, metal shrapnel or bullet or metallic implant in the region of the target knee joint), pregnancy, lactating women, renal insufficiency (defined by a glomerular filtration rate of
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoints in this study are the correlation coefficients between the in vivo outcomes of the quantitative MRI and CT techniques under investigation and the in vitro reference standards for cartilage sGAG and collagen content. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint of this study is the relation between the outcomes of the DCE-MRI and the outcomes of the WOMAC and ICOAP questionnaires. | — |
Countries
Netherlands
Outcome results
None listed