Functional connectivity and neuronal networks in brain tumor patients with epilepsy

Functional connectivity and neuronal networks in brain tumor patients with epilepsy - Brain networks and epilepsy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37154

Enrollment

Registered

2008-06-04

Start date

2008-06-18

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain tumor Seizures

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for glioma patients: (1) adult (> 18 years) (2) epilepsy (at least one epileptic seizure) (3) histopathologically confirmed glioma or meningioma according to the WHO (4) written informed consent.;Inclusion criteria for healthy controls (1) adult (> 18 years) (2) written informed consent;Inclusion criteria for language side-study (amendment): (1) received intraoperative language mapping (2) received resective brain surgery in the dominant hemisphere (3) Dutch is native language

Exclusion criteria

Exclusion criteria: Exclusion criteria for glioma patients: (1) psychiatric disease or symptoms (2) insufficient mastery of the Dutch language (3) inability to communicate adequately;Exclusion criteria for healthy controls: (1) use of centrally acting drugs (including analgetics) (2) psychiatric disease or symptoms (3) disorders of the central nervous system (4) insufficient mastery of the Dutch language

Design outcomes

Secondary

Measure	Time frame
cognition Language-study The secondary study parameters are the neuropsychological tests obtained pre- and postoperatively by a neuropsychologist.	—

Primary

Measure	Time frame
- MEG-measures: clustercoefficient padlength synchronisation likelihood - epilepsy diary (frequency and severity) and epilepsy burden Language-study The main study parameters are an extensive language task, a naming task and a language performance questionnaire assessing functional outcome in patients who received resective brain surgery after intraoperative language mapping. The language task will measure language performance in various domains, e.g. speaking, listening, reading and writing, whereas the questionnaire will obtain information on how patients perceive their own language performance. The naming task will measure performance pre and post operatively.	—

Measure

Time frame

- MEG-measures: clustercoefficient padlength synchronisation likelihood - epilepsy diary (frequency and severity) and epilepsy burden Language-study The main study parameters are an extensive language task, a naming task and a language performance questionnaire assessing functional outcome in patients who received resective brain surgery after intraoperative language mapping. The language task will measure language performance in various domains, e.g. speaking, listening, reading and writing, whereas the questionnaire will obtain information on how patients perceive their own language performance. The naming task will measure performance pre and post operatively.

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Countries

Netherlands

Outcome results