er wordt gekeken naar de reactiesnelheid na het geven van anesthesie reponse time sedation
Conditions
Interventions
None listed
Sponsors
anesthesiologie- onderzoeksbureau
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age 50 * 72 years
Exclusion criteria
Exclusion criteria: -Volunteer refusal - Significant cardiovascular or respiratory disease - Vascular contra-indication for arterial line placement -Loss of strength, motor skills or sensibility of the hands or arms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response times (squeezing the handset in response to vibration of a wrist device) will be recorded electronically (automatically) during increasing and decreasing sedation levels provided by a standardized effect-site targeted infusion algorithm administered by means of the RUGLOOP II system | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters will be recordings of routine physiological parameters (respiratory rate, oxygen-haemoglobin saturation, heart rate, blood pressure), propofol doses, propofol blood concentrations and computer estimates of blood and brain concentrations, and electronic recordings of the electroencephalogram (which will undergo offline analysis to calculate various processed EEG parameters and other parameters of depth of sedation). | — |
Countries
Netherlands
Outcome results
None listed