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REACT-2; Randomized study of the early assessment by CT scanning in trauma patients

REACT-2; Randomized study of the early assessment by CT scanning in trauma patients - Primary total body CT scanning in severely injured trauma patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON37113
Enrollment
450
Registered
2011-11-14
Start date
2011-04-20
Completion date
Unknown
Last updated
2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ernstige traumatische letsels trauma injury

Interventions

the total body CT scan without prior conventional imaging

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: At least one of the following parameters at hospital arrival: - respiratory rate *30 or *10, or - pulse *120/min - systolic blood pressure *100 mmHg - exterior blood loss *500 ml - Glasgow Coma Score *13 or abnormal pupilary reaction on site.;Or one of the following clinically suspicious diagnoses: - Patients with signs of fractures from at least two long bones - Patients with clinical signs of flail chest, open chest or multiple rib fractures - Patients with clinical signs of severe abdominal injury - Patients with a clinically evident pelvic fracture - Patients with signs of unstable vertebral fractures or signs of spinal cord compression;Or one of the following injury mechanisms: - fall from height (>3 meters / > 10 feet) - ejection from the vehicle - death occupant in same vehicle - severely injured patient in same vehicle - wedged or trapped chest / abdomen

Exclusion criteria

Exclusion criteria: - Age

Design outcomes

Primary

MeasureTime frame
The in-hospital mortality

Secondary

MeasureTime frame
- The difference in mortality: the 24hour mortality and the mortality during the first year after the trauma. - The difference in morbidity: the complications and total number of re-interventions and re-admissions during the first year after the trauma. - The difference in hospital time: the length of in-hospital and ICU stay and the total number of ventilation days. - The difference in quality of life 6 and 12 months after the trauma as recorded by filling in two questionnaires (HUI-3 and EuroQoL). - The difference in ratio of non-operative management strategies: i.e. conservative and angio-interventional treatment versus primary operations. - The difference in radiation exposure between total body CT and standard work-up. - The difference in diagnostic time and between total body CT and standard work-up. - The difference in cost-effectiveness (measured by a patient questionnaire derived from the Dutch Labour and Health Questionnaire and adapted for international use 3 and 6 months after the trauma). - The difference in diagnostic accuracy between total body CT and standard work-up.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)