Prospective, multicenter, randomized controlled trial towards identifying the optimal Cetrotide treatment protocol

Prospective, multicenter, randomized controlled trial towards identifying the optimal Cetrotide treatment protocol - CETRO Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37107

Enrollment

2430

Registered

2008-08-11

Start date

2009-03-12

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IVF/ICSI infertility

Interventions

Two different GnRH antagonist treatment protocols used in daily practice will be compared. Patients will be randomized to receive one of the following two treatments: Early fixed start: start GnRH a

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Women

Exclusion criteria

Exclusion criteria: More than 2 previous unsuccessful IVF/ICSI cycles

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the live birth rate per started cycle. Live birth from cryopreserved embryos originating from, and occurring within 6 months of the initial treatment cycle will be included in the total live birth rate per started cycle.	—

Secondary

Measure	Time frame
Ongoing, clinical and biochemical pregnancy rate Incidence of premature LH rise as detected on day of hCG administration LH, E2, P4 levels on CD2, CD6 and day of hCG administration Number of retrieved oocytes Total number of embryos available for transfer Number of embryos suitable for transfer Implantation rate per ET Endometrial thickness on ultrasound examination on day of oocyte pick-up QALY assessment	—

Measure

Time frame

Ongoing, clinical and biochemical pregnancy rate Incidence of premature LH rise as detected on day of hCG administration LH, E2, P4 levels on CD2, CD6 and day of hCG administration Number of retrieved oocytes Total number of embryos available for transfer Number of embryos suitable for transfer Implantation rate per ET Endometrial thickness on ultrasound examination on day of oocyte pick-up QALY assessment

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)