obesitas obesity and insulin resistance
Conditions
Interventions
None listed
Sponsors
Unilever
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male sex - Aged 30-70 years - Obesity (>30 kg/m2) - insulin resistance as fasting glucose levels >6.1 mmol/L - Reported intense sport activities
Exclusion criteria
Exclusion criteria: - BMI >=40 kg/m2 - Presence of cardiovascular disease - Presence of sudden cardiac death in a 1st degree relative at an age 2 cups per day)29 - Prescribed medical treatment that may affect the cardiovascular system - Reported use of any medically- or self-prescribed diet - Reported weight loss or gain >10% during a period of 6 months prior to the study - Subjects who participated in studies with a drug and/or nutritional intervention and without risks for carry-over effects are excluded for 1 month from participation in this study - Reported participation in night shift work two weeks prior to the study or during the study (defined as working between midnight and 6.00 am)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral vascular resistance after a 75 gr glucose load combined with water/tea/beetroot juice, where vascular resistance is calculated as the product of blood flow as measured by venous occlusion plethysmography and arterial blood pressure by the Finapress (in mmHg/100 mL tissue/min). The area-under-the-curve of the peripheral vascular resistance in the forearm and leg is calculated up to 3 h after the glucose load. | — |
Countries
Netherlands
Outcome results
None listed