Validation of [18F]FES for imaging of brain estrogen receptors

Validation of [18F]FES for imaging of brain estrogen receptors - [18F]FES for imaging of brain ER

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37068

Enrollment

Registered

2012-08-09

Start date

2013-01-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gezonde deelnemers healthy controls

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Female - Age > 18 years - For postmenopausal women: at least 1 year after menopause - For premenopausal women: a regular menstruation - Signed written informed consent

Exclusion criteria

Exclusion criteria: - Use of estrogen receptor ligands - History of ER-positive malignancies or breast cancer - Use of any contraceptive drug (pill, injections or implanted) - For postmenopausal women: (history of) estrogen replacement therapy - Pregnancy - History of removal of the ovaries and/or the uterus - Current systemic and or major metabolic diseases - Somatic, organic or neurological disorders - Recent participation in a scientific research study (

Design outcomes

Primary

Measure	Time frame
The main study parameters are the binding potential and distribution volume of [18F]FES in the human brain, derived from kinetic modelling using an arterial input function, reference tissue modelling and an image derived input function.	—

Secondary

Measure	Time frame
A secondary study parameter is the level of estradiol in serum.	—

Countries

Netherlands

Outcome results