Anastomotic dehiscence Anastomotic leakage
Conditions
Interventions
None listed
Sponsors
Atrium Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients who will undergo one of the following types of surgery will be included: - (partial) colectomy with a primary anastomosis - esophagectomy with gastric interposition - (partial) gastrectomy
Exclusion criteria
Exclusion criteria: Previous gastro-intestinal surgery in the last 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following serum blood values will be measured and their relationship with anastomotic leakage will be analyzed between patients with anastomotic leakage and control patients without anastomotic leakage. * Leucocyte count and differentiation * C-reactive protein * Procalcitonin * Lactate * Creatinin The outcome of the study is the occurrence of anastomotic leakage confirmed by CT, water soluble enema, explorative surgery or pathology within 28 days after initial surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, the following clinical parameters and patient characteristics will be recorded and compared between patients with anastomotic leakage and control patients without anastomotic leakage. * Age * Gender * American Society of Anesthesiologists (ASA) classification * Body mass index (BMI) * Intoxication (smoking, alcohol, drugs) * Malnutrition universal screening tool (MUST) score * Systemic steroid or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) use in the last 4 weeks * Diabetes mellitus * Cardiac comorbidity * Pulmonary comorbidity * Neoadjuvant therapy * Laparoscopy or open * Distance of anastomosis to anal verge * Protective stoma * Additional procedures * Peroperative blood loss * Number of peroperative blood transfusions * Duration of operation * Severity of peritonitis as scored by operating surgeon on a 1-5 scale * Quality of anastomosis as scored by operating surgeon on an 1-5 scale * Need for and duration of mechanical ventilation or oxygen support * Need for inotropic drugs. * Patient wellness scored on a three-point scale by the physician * Duration of hospital admission If possible, together with the results of the laboratory tests, these parameters will be combined into a score to early detect anastomotic leakage in future patients. | — |
Countries
Netherlands
Outcome results
None listed