carbohydrates hyperglycemia
Conditions
Interventions
12 volunteers will participate in the study
each person will be studied on two
different occasions at least one week apart, consuming 8 gram butter lettuce
(Lactuca sativa var. Capitataor) or 8 gram BroccoCress. 45 minutes after either
lettu
4 volunteers will participate in the study
each person will be studied on one
occasion, consuming 8 gram BroccoCress (of which 4 gram will be labelled with
13C). 45 minutes after BroccoCress a first glucose load (75 gram glucose) will
be in
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy men
Exclusion criteria
Exclusion criteria: Clinical singificant abnormalities at medical research Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial inflammation will be tested by measuring nuclear NF-*B abundance in peripheral blood mononuclear cells and by measuring plasma cytokine concentrations. In addition, postprandial insulin sensitivity will be determined by measuring plasma concentrations of glucose and insulin as well as glucose uptake in peripheral tissues using dual isotope labelling. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the effect of BroccoCress on insulin sensitivity after a 2nd glucose load Monitor the bioavailability and kinetics of SFN and related metabolites in blood and urine | — |
Countries
Netherlands
Outcome results
None listed