Macrophage infiltration and adipocytokine expression in subcutaneous and visceral fat tissue in patients with Cushing's syndrome.

Macrophage infiltration and adipocytokine expression in subcutaneous and visceral fat tissue in patients with Cushing's syndrome. - Metabolic changes in Cushing's syndrome fat tissue.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37047

Enrollment

Registered

2012-11-23

Start date

2013-02-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cushing's syndrome hypercortisolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - patients with active Cushing's syndrome during adrenalectomy, confirmed by increased 24h urine cortisol excretions and a positive dexamethasone supression test. - over 18 years old. - informed consent

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
- a) amount of macrophage infiltration in fat tissue - b) mRNA expression of adipokines - c) mRNA expression of proinflammatory cytokines cytokines and adipokines that can be measured in blood of patients suffering from Cushing's syndrome and controls.	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results