exercise-induced cTnT release exercise-induced heart damage
Conditions
Interventions
After an initial screening, subjects will be randomly assigned to a test day
during which they receive a sodium nitrate (test supplement) or sodium chloride
(placebo) supplement. During each test da
Sponsors
Human Movement Sciences
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -type 2 diabetes -exercise-induced rise in cardiac troponin T (>3 ng/L)
Exclusion criteria
Exclusion criteria: -HbA1c 10.0% -diagnosed impaired renal or liver function -morbid obesity (BMI>35 kg/m2) -incident cardiovascular events in the last year (heart attack, stroke, aneurysms) -treatment with medication which contain nitrates and/or having vasodilatory effects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTnT levels at baseline and over the subsequent 6 h period following exercise | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma nitrate and plasma nitrite concentrations Blood pressure measured at 8:00, 9:30, 10:00, 10:30, 11:00, 12:15, 14:00 and 16:00 h. Orthogonal polarization spectroscopy (OPS) will be applied at 8:00, 10:00, 11:00 and 13:30 and 16:00 h. This non-invasive method has proven to quantify microvascular flow and endothelium permeability for erythrocytes in the oral cavity. | — |
Countries
Netherlands
Outcome results
None listed