The influence of sarcopenia and cancer cachexia on recovery of gastric and colonic surgery

The influence of sarcopenia and cancer cachexia on recovery of gastric and colonic surgery - Sarcopenia in gastric and colonic surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37020

Enrollment

Registered

2012-07-11

Start date

2012-11-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer gastric cancer sarcopenia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing gastric or colonic resection of a primary tumor who are older than 80 years or younger than 60 years of age. Surgery types: gastric: BII subtotal gastrectomy, total gastrectomy with Roux and Y reconstruction. Colon: right hemicolectomy, left hemicolectomy, sigmoid resection. Both open resections and laparoscopic resection will be included. Patients undergoing abdominal wall incisional hernia repair who are older than 80 years or younger than 60 years of age.

Exclusion criteria

Exclusion criteria: Metastasized tumors (TNM stage M1 or higher). To avoid variation of tumorload within patient groups, patients with metastases beyond lymph nodes will be excluded. Acutely ill patients will be excluded as this influences inflammatory markers. Acutely ill is defined as: pneumonia, urinary tract infection, (intra-abdominal) abscess, etc.

Design outcomes

Primary

Measure	Time frame
On frozen sections of muscle biopsies, the next parameters will be investigated: fiber typing, quantity of fibers, mean fiber cross sectional area, the number of satellite cells per fiber. Moreover, apoptosis is studied, which is an important process prior to muscle wasting in cancer patients. The primary study outcome is the difference in muscle composition between elderly (>80) and younger (	—

Secondary

Measure	Time frame
Fat tissue: inflammation. Colonic tissue: collagen composition, proliferation, inflammation, apoptosis, goblet cells, mucins and prostaglandins. These factors have an important function in intestinal healing. Gastric tissue: collagen composition, proliferation, inflammation, apoptosis and prostaglandins. These factors have an important function in gastric healing. Plasma: inflammation, markers of intestinal damage.	—

Measure

Time frame

Fat tissue: inflammation. Colonic tissue: collagen composition, proliferation, inflammation, apoptosis, goblet cells, mucins and prostaglandins. These factors have an important function in intestinal healing. Gastric tissue: collagen composition, proliferation, inflammation, apoptosis and prostaglandins. These factors have an important function in gastric healing. Plasma: inflammation, markers of intestinal damage.

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Countries

Netherlands

Outcome results