A phase 0 study to investigate the effects of inhaled and intranasal lipopolysaccharide (LPS) on pro-inflammatory markers sampled by hypertonic saline sputum induction (SI) and nasal lavage (NAL) in healthy subjects. Part 1 with 0,9% NaCl.

A phase 0 study to investigate the effects of inhaled and intranasal lipopolysaccharide (LPS) on pro-inflammatory markers sampled by hypertonic saline sputum induction (SI) and nasal lavage (NAL) in healthy subjects. Part 1 with 0,9% NaCl. - 125633-CS-00186

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36988

Enrollment

Registered

2012-08-16

Start date

2012-08-20

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma COPD

Interventions

nap

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Healthy M/F subjects, aged 18-55 yrs. - FVC, FEV1 >=80% ; FEV1/FVC ratio >=0.75. - Oxygen saturation >=94% (pulsoximetry). - Normal blood pressure (SBP 90-150, DBP 60-90 mmHg, inclusive) and pulse (45-100 bpm, inclusive) - ECG without clinically relevant abnormalities.

Exclusion criteria

Exclusion criteria: - History of upper and lower airway infection 1 yr,

Design outcomes

Primary

Measure	Time frame
nap	—

Secondary

Measure	Time frame
nap	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)