Obesity
Conditions
Interventions
This research consists of 6 treatment days. Each treatment day one of the
following combinations of food will be researched:
1. 200 mL vodka orange juice mix + 40 g cake for consumption
2. 200 mL vod
Sponsors
TNO
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Caucasian men, this means that at least both parents and the subject himself should be of the Caucasian race; 2. Age 25-50 years (inclusive) on the day of the screening; 3. Body Mass Index (BMI) of 20-25 kg/m2 (inclusive); 4. Body weight of 60-100 kg (inclusive); 5. Able to read, write and fully understand the Dutch language, and 6. Able to participate in the study, willing to give written informed consent and to comply with the study procedures and restrictions
Exclusion criteria
Exclusion criteria: 1. Above average score (>2.26) on the restrained eating scale of the Dutch Eating Behaviour Questionnaire; 2. Alcohol consumption = 21 standard glasses/week; 3. Not having regular and normal Dutch eating habits (consuming mostly 3 main meals including breakfast); 4. Not having a normal day/night rhythm; 5. Smoking, or stopped with smoking 4 kg in the month prior to screening; 14. Inappropriate veins for cannula insertion; 15. Not having a general practitioner or health insurance; 16. Having a history of medical or surgical events or disease that may significantly affect the study outcome, particularly physiological disorders, metabolic or endocrine disease and gastrointestinal disorders; and/or 17. Any conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Questionnaire measuring food wanting explicitly (VASfood) - Questionnaire measuring food wanting explicitly for different food categories (LFPQ) - Computer task measuring food wanting implicitly for different food categories (LFPQ) - Questionnaire measuring food liking explicitly for different food categories (LFPQ) - Questionnaire measuring hunger, fullness and prospective food consumption (VASfood) - Ad libitum food intake - Breath alcohol concentration | — |
Secondary
| Measure | Time frame |
|---|---|
| - Computer task measuring food preferences (LFPQ) - GLP-1 in plasma - Ghrelin in plasma - N-acyl ethanolamides in plasma - Leptin, Insulin, FFA and glucose in serum - Ghrelin in saliva - N-acyl ethanolamides in saliva | — |
Countries
Netherlands
Outcome results
None listed