Late term complications after radiotherapy of the neck; Cognitive functioning and gait.

Late term complications after radiotherapy of the neck; Cognitive functioning and gait. - Late term complications after radiotherapy of the neck

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36964

Enrollment

Registered

2012-08-23

Start date

2012-11-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke vascular injury

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: RT of the neck because of a T1/T2 (N0M0) laryngeal carcinoma, T1/T2 (N0M0) parotid carcinoma / pleomorphic adenoma, T1/2 (N1/2M0) oro/hypopharynxcarcinoma or non-Hodgkin/Hodgkin lymphoma and a minimal follow-up of 6 years post RT.

Exclusion criteria

Exclusion criteria: History of cerebrovascular disease, pregnancy or breast-feeding, ongoing treatment with an HMG-coA reductase or cytochroom P450 inhibitor, active liver disease or > 3 times the upper limit of serum transaminases, 5 times the normal level of creatine phosphokinase, serum cholesterol > 7 mmol/L and a life expectancy

Design outcomes

Primary

Measure	Time frame
Incidence, location and composition of extra- and intracranial postirradiation vessel wall assessed by MRI/A and duplexultrasonography.	—

Secondary

Measure	Time frame
- Incidenc of white matter lesions, (silent) brain infarctions and atrophy, assessed bij MRI/A - Incidence cardio and cerebrovascular diseases - Scores on balans and gaith parameters - Incidence cognitive dysfunctioning, assessed by a neuropsychological excamination	—

Countries

Netherlands

Outcome results