chronic airflow limitation chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: Clinically stable COPD patients with GOLD I (=mild COPD, a FEV1/VC ratio (forced expiratory volume in one second divided by the vital capacity) = 80% of predicted)and >= 18 years old. Controls: Subjects with normal lung function and with similar ages and gender distribution as the patients with COPD
Exclusion criteria
Exclusion criteria: Patients: patients with long term oxygen therapy at home, with co-existing lung disease other than COPD (including asthma), with restrictive lung function, with other exercise-limiting disorders than COPD like cardiac or neuromuscular disease, or patients using β-blockers are excluded from the study. Controls: subjects with abnormal lung function or history of lung disease or with exercise-limiting disorders like cardiac or neuromuscular disease are excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For the first objective, the main study parameter is the percentage of subjects that show dynamic hyperinflation during ADL. For the second objective, the main study parameter is the difference in dynamic hyperinflation during ADL between baseline and after two years of follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured during ADL: Ventilatory parameters: ventilation (Ve), breathing reserve (BR), Ve/maximal ventilatory capacity (MVC), ventilatory equivalent for CO2 (Ve/VCO2), partial pressure of end-tidal CO2 (PetCO2), breathing frequency (BF). Operational lung volumes: inspiratory reserve volume (IRV), tidal volume (Vt) Cardiovascular parameters: heart rate (HR), HR reserve, O2-pulse, blood pressure Other: oxygen consumption (VO2), dyspnea, ADL-time, gas exchange | — |
Countries
Netherlands
Outcome results
None listed