Effective treatment of adolescents with aggression problems in clinical and non clinical settings

Effective treatment of adolescents with aggression problems in clinical and non clinical settings - Treatment of Aggression (TOA)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36905

Enrollment

150

Registered

2013-02-15

Start date

2013-02-25

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aggressive behaviour among adolescents. ODD en CD diagnoses

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Full scale IQ at least 80; PIQ = 80 -Minimal score on MOAS of 5 on both initial screenings -Age lies between 12 and 18 years -Minimal motivation among participant and family -Reading level of Avi 6 or 7. -Clinical diagnosis of ODD, CD based on DISC-IV

Exclusion criteria

Exclusion criteria: - Previous ART (half year before ) -Psychotic condition - Severe depression -Severe substance dependency - Suicidal - Recently started medication (less than 2 weeks before ART training)

Design outcomes

Primary

Measure	Time frame
We aim to compare the cognitive and behavioural profiles of treatment responders, non-responders and drop outs in relation to genetic susceptibility and across various contexts (schools, centre for Orthopsychiatry and residential youth care agency). Our main question of enquiry here is: what behavioural, cognitive and genetic profiles regarding aggressive behaviour and correlates relating to aggressive behaviour can be found among responders and non responders? -It is hypothesised that non responder profiles shows lower levels of moral reasoning and social skills, more proactive aggression, a higher sensitivity towards reward, a more risk taking cognitive profile, and a higher genetic susceptibility (specifically a higher activity of the MAO-A gene) and higher levels of callous and or unemotional traits at baseline. However high levels of impulsiveness could also be a trait of non responders.	—

Measure

Time frame

We aim to compare the cognitive and behavioural profiles of treatment responders, non-responders and drop outs in relation to genetic susceptibility and across various contexts (schools, centre for Orthopsychiatry and residential youth care agency). Our main question of enquiry here is: what behavioural, cognitive and genetic profiles regarding aggressive behaviour and correlates relating to aggressive behaviour can be found among responders and non responders? -It is hypothesised that non responder profiles shows lower levels of moral reasoning and social skills, more proactive aggression, a higher sensitivity towards reward, a more risk taking cognitive profile, and a higher genetic susceptibility (specifically a higher activity of the MAO-A gene) and higher levels of callous and or unemotional traits at baseline. However high levels of impulsiveness could also be a trait of non responders.

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Secondary

Measure	Time frame
Is ART effective in reducing aggressive behaviours (proactive or reactive) among patients with a disorder of aggression regulation? Are genetic risk factors for ADHD, CD and ODD as discovered by hypothesis-free genetic studies, predictive for treatment response to ART? It is hypothesized that after 10 weeks of follow up measurements on the Modified Overt Aggression Scale (MOAS; Kay et al. 1988) the ART will prove to be effective to reduce the frequency and severity of aggressive behaviours.	—

Measure

Time frame

Is ART effective in reducing aggressive behaviours (proactive or reactive) among patients with a disorder of aggression regulation? Are genetic risk factors for ADHD, CD and ODD as discovered by hypothesis-free genetic studies, predictive for treatment response to ART? It is hypothesized that after 10 weeks of follow up measurements on the Modified Overt Aggression Scale (MOAS; Kay et al. 1988) the ART will prove to be effective to reduce the frequency and severity of aggressive behaviours.

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Countries

Netherlands

Outcome results