Heart failure and iron deficiency
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For all participants: 1. Patients 18 years or older. 2. Able to understand the procedures and are willing to provide informed consent.;For cardiac patients: 1. Accepted and scheduled for cardiothoracic surgery (coronary artery bypass graft surgery) at the Department for Cardiothoracic Surgery. 2. A known LVEF, either assessed by echocardiography, MUGA-scan or MRI-scan. If LVEF 125 pg/mL. ;For non-cardiac patients: 1. Accepted and scheduled for total hip/knee replacement at the Department for Orthopedic Surgery. 2. No manifestations of diabetes and with
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years of age. 2. An unstable medical condition, defined as having been hospitalized for a non-cardiac condition within 4 weeks of screening, or otherwise unstable in the judgment of the investigator (e.g. at risk of complications or adverse events unrelated to study participation). 3. History of acquired iron overload 4. Severe concomitant renal failure (eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter/endpoint * Sensitivity and specificity (percentages) of possible novel serum markers reflecting iron status compared to BM iron staining. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences between iron deficient and non-iron deficient patients and between patients with and without HF: 1. Baseline characteristics (e.g. age, sex, NYHA class, medical history). 2. Right and left ventricular systolic and diastolic function. 3. Blood and urine markers (e.g. hemoglobin, inflammation, renal function, N-terminal pro-brain-type natriuretic peptide). 4. Rate and severity of eryptosis (e.g. more cell shrinkage). 5. Vital status/hospitalisations. | — |
Countries
Netherlands
Outcome results
None listed