Heparin sensitivity in cardio-thoracic surgery: the effect of surgical trauma

Heparin sensitivity in cardio-thoracic surgery: the effect of surgical trauma - HepSens study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36891

Enrollment

Registered

2012-08-15

Start date

2012-09-14

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac valve surgery Coronary artery bypass graft surgery

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients scheduled for coronary artery bypass grafting (CABG) or cardiac valve surgery with cardiopulmonary bypass Age 18-85 years Informed consent

Exclusion criteria

Exclusion criteria: Re-operations Emergency operation Patients with insulin-dependent diabetes mellitus Patients with a history of hematologic, hepatic or renal diseases Patients with Body Mass Index (BMI) over 30 kg/m2 Patients with anemia (Hb

Design outcomes

Primary

Measure	Time frame
Difference in heparin sensitivity between patients undergoing CABG and cardiac valve surgery Differences in rotational thromboelastometry and platelet aggregometery between groups Heparin and protamine dosing	—

Secondary

Measure	Time frame
Classical coagulation tests (aPTT, PT, platelet count) Hemoglobin, hematocrit Demographic variables, fluid intake, perioperative medication Surgical characteristics Microparticles	—

Countries

Netherlands

Outcome results