Effect of noninvasive ventilation on the synchrony of the upper airways and inspiration.

Effect of noninvasive ventilation on the synchrony of the upper airways and inspiration. - NIV and glottis-diaphragm synchrony.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36867

Enrollment

Registered

2012-08-30

Start date

2012-10-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease (COPD) lung emphysema

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) Age >18 2) Informed consent 3) COPD 4) Hypercapnic respiratory acidosis 5) Clinical need of NIV ventilation on the intensive care 6) NAVA catheter in situ

Exclusion criteria

Exclusion criteria: 1) Pre-existent muscle disease (congenital or acquired) or diseases / disorders known to be associated with myopathy including auto-immune diseases. 2) Upper airway/esophageal/mouth or face pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia) 3) Diabetes 4) Recent (

Design outcomes

Primary

Measure	Time frame
The main study parameter is the extent of glottis closure during diaphragm activation and the time delay in glottis opening with respect to diaphragm activity.	—

Secondary

Measure	Time frame
Secondary objectives are to investigate whether the level of support and the triggering mode of noninvasive ventilation induces or influences glottis behavior.	—

Countries

Netherlands

Outcome results