Ventilator induced lung injury by mechanical ventilation in children with respiratory syncytial virus infection.

Ventilator induced lung injury by mechanical ventilation in children with respiratory syncytial virus infection. - VILI-RSV

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36852

Enrollment

Registered

2009-03-11

Start date

2009-11-05

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bronchiolitis Respiratory syncytial virus infection

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Index group (n

Exclusion criteria

Exclusion criteria: * Previous airway morbidity in all groups * Severe co-morbidity (p.e. congenital heart disease, prematurity

Design outcomes

Primary

Measure	Time frame
An undiluted nasopharyngeal aspirate (NPA) will be taken within 1 hour before intubation followed by an endotracheal aspirate (ETA) at 6, 24 and 48 hours after intubation. In non-intubated patients a NPA will be taken at 0, 6, 24 and 48 hours after the first NPA. Cytokine concentrations in NPA /ETA will be determined; IL-1, IL-6, TNF-*, IL-10 and IL-8 will be measured using the Luminex fluorescent-bead-based technology. Of the ventilated patients, 2 ml blood will be collected every 48 hours for immunological studies.	—

Measure

Time frame

An undiluted nasopharyngeal aspirate (NPA) will be taken within 1 hour before intubation followed by an endotracheal aspirate (ETA) at 6, 24 and 48 hours after intubation. In non-intubated patients a NPA will be taken at 0, 6, 24 and 48 hours after the first NPA. Cytokine concentrations in NPA /ETA will be determined; IL-1, IL-6, TNF-*, IL-10 and IL-8 will be measured using the Luminex fluorescent-bead-based technology. Of the ventilated patients, 2 ml blood will be collected every 48 hours for immunological studies.

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Countries

Netherlands

Outcome results