skincancer Squamous cell carcinoma
Conditions
Interventions
Patients in the treatment group are treated with Mohs' micrographic surgery
under local anesthesia. The squamous cell carcinoma will be removed with a
margin of 2-3mm and frozen sections will be mad
Sponsors
Catharina-ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Histologically confirmed cutaneous squamous cell carcinoma T1, stage 1, without high-risk characteristics. Squamous cell carcinoma at sun-exposed sides excluding lip and ear, tumour smaller than 20mm in diameter, tumours smaller than 4mm in dept and confined to the dermis, histologically well to moderately differentiated or verrucous subtype and without evidence of immune dysfunction.
Exclusion criteria
Exclusion criteria: Squamous cell carcinoma >= TNM II of the ear, lip and non-exposed sites (e.g. perineum, sacrum, sole of foot), arising in areas of radiation, chronic ulcers, tumours greater than 20mm in diameter, tumours greater 4mm in dept or extending down to the subcutaneous tissue, poorly differentiated, perineural involvement, acantolytic, incomplete excision, desmoplastic characteristics, angio-involvement, recurrent tumours, positive lymph nodes, immunosuppressive therapy (e.g. after organ transplantation), chronic immunosuppressive disease. Bowen*s disease, mucosal squamous cell carcinoma and actinic keratosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of Mohs' micrographic surgery compared to surgical excision is measured according to three primary outcome measures: 1. Throughput time, 2. Quality of life and 3. Patient satisfaction. The throughput time is the time from the first contact at the out patient clinic untill the end of the treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| As a secondary outcome we will study recurrence rate and costs of both treatments. | — |
Countries
Netherlands
Outcome results
None listed