Barrett's esophagus cancer
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria *dysplastic* group: - Scheduled ER for Barrett*s esophagus containing HGD or early cancer; - Review of biopsies and histopathology specimens by an expert local pathologist; - Written informed consent;Inclusion criteria *non-dysplastic* group: - Scheduled surveillance endoscopy for Barrett*s esophagus without dysplasia; - No dysplasia in biopsies, or biopsies *indefinite for dysplasia* during at least the last two years; - No visible abnormalities in Barrett*s esophagus in the two most recent surveillance endoscopies; - Review of biopsies and histopathology specimens by an expert local pathologist; - Written informed consent
Exclusion criteria
Exclusion criteria: Exclusion criteria *dysplastic* group: - In case histopathological assessment of the frozen half of the ER specimen is necessary for clinical decision making, the specimen will be retrieved from the Barrett*s research tissue bank and further processed for clinical care.;Exclusion criteria *non-dysplastic* group: - Patients that are not suitable candidates for ER because of co-morbidity;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Identification of peptides and proteins that may indicate the presence of early neoplasia in Barrett*s. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Number of proteins found per cell surface area; - Differences and similarities in protein profiles of 10 dysplastic versus 10 non-dysplastic specimens in 1) epithelial and 2) stromal cells; | — |
Countries
Netherlands
Outcome results
None listed