Genome wide association study on remission of asthma

Genome wide association study on remission of asthma - GWAs on asthma remission

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36808

Enrollment

119

Registered

2011-03-22

Start date

2011-06-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older. 2. Previous diagnosis of asthma 3. Included in the GWA-study on asthma ;Additional inclusion criteria for the performance of spirometry and a histamine provocation test: 4. No current asthma symptoms 5. No use of asthma medication

Exclusion criteria

Exclusion criteria: 1. Presence of serious concomittant diseases 2. Pregnancy Additional exclusion criterium for histamine provocation testing: 3. FEV1 lower than 1.2 L

Design outcomes

Primary

Measure	Time frame
Presence of complete asthma remission: no current asthma symptoms (asthma attacks, wheeze), no current use of asthma medication, FEV1 pre bronchodilator > 80% predicted, no bronchial hyperresponsiveness (PC20 histamine > 32 mg/ml). Associations between the single nucleotide polymorphisms genotyped in the GWA study and the presence of complete asthma remission will be studied using logistic regression analysis.	—

Measure

Time frame

Presence of complete asthma remission: no current asthma symptoms (asthma attacks, wheeze), no current use of asthma medication, FEV1 pre bronchodilator > 80% predicted, no bronchial hyperresponsiveness (PC20 histamine > 32 mg/ml). Associations between the single nucleotide polymorphisms genotyped in the GWA study and the presence of complete asthma remission will be studied using logistic regression analysis.

—

Countries

Netherlands

Outcome results