Movement Diagnostic System: Quantitative diagnosis of patients with Parkinson's Disease, essential tremor and dystonia, a closed-loop approach with fMRI

Movement Diagnostic System: Quantitative diagnosis of patients with Parkinson's Disease, essential tremor and dystonia, a closed-loop approach with fMRI - Movement Diagnostic System

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36806

Enrollment

100

Registered

2012-02-01

Start date

2011-12-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

involuntary movements movement disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • 18 years or older • Right-handed according to the Edinburgh Handedness Inventory • Willingness to stop medication intake for eight hours prior to investigations And either: • Essential tremor according to criteria defined by the Tremor Investigation Group, moderate to severe tremor (Tremor Rating Scale Part A 2 UE>2) ; Hereditary ET (positive family history: at least one affected relative in immediate family; Onset in patient and family member before age 65); Positive effect of propranolol on tremor. • Parkinson*s disease according to the UK Brain Bank criteria for Parkinson*s disease; No major fluctuations in symptoms due to medication; No severe dyskinesia. • Limb dystonia with at least 35 points on the motoric part of the Burke-Fahn-Marsden Dystonia Rating Scale • Healthy age and sex-matched controls

Exclusion criteria

Exclusion criteria: • MR-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation and pacemakers. • Other contraindications for MR (Claustrophobia, obesity, etc.) • Use of medicines/drugs that could influence the performance during the tasks (such as anti-epileptic drugs, neurodepressants, etc.) • Pregnancy or suspected pregnancy • Incapability to give informed consent • Other neurological disorder than ET/PD-T/dystonia including dementia • Abnormalities of the hand/wrist or prior surgery of the hand/wrist

Design outcomes

Primary

Measure	Time frame
Differentiation between ET, PD-T and DYS based on brain activations specifically related to involuntary movements. With external measures and perturbation of the closed sensorimotor loop during fMRI we expect to find involvement of the olivocerbellar networks in ET, the striatum in PD-T and a widespread involvement of basal ganglia, thalamus, and cerebral cortex in dystonia.	—

Secondary

Measure	Time frame
Observation and identification of the brain regions involved in (the early stages) of movement disorders with overlapping symptoms will contribute to the knowledge on the occurrences and causes of these diseases on a more fundamental level.	—

Countries

Netherlands

Outcome results