liver cirrhosis liver scarring
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy controls (population A): - minimum age of 18-years old - decision making capacity;Patients (group B) (minimum of 18 years old) with cirrhosis, as diagnosed by a GE-specialist, due to one of the following chronic liver diseases: Primary Biliairy Sclerosis (PBS), Primary Sclerosis Cholangitis (PSC), Hepatitis B, Hepatitis C, Non-Alcoholic Fatty Liver Disease (NAFLD), Alcoholic Liverdisease, Non-Alcoholic Steatosis Hepatitis (NASH), Haemochromatosis, Cryptogenic levercirrhosis.
Exclusion criteria
Exclusion criteria: For both healthy controls (population A) as patients (population B): - proven congenital diseases concerning primary hemostasis (e.g. M. von Willebrand), defects in fibrinolysis, coagulation factor deficiencies (e.g. hemophilia A and B), vasculair defects which leed to higher bleeding risk (e.g. M. Rendu-Osler-Weber). Patients using medication interfering with primary hemostasis or coagulation. Coagulation factor deficiencies due to malignancies, sepsis or trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombin Generation Curve in PPP (platelet poor plasma) and PRP (platelet rich plasma) using CAT Thrombocyte function test using the Multiplate (aggregometer) Measurement of the fibronolysis pathway by use of the Fibrinolysis ROTEM Measurement of microparticles with influence on the haemostasis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Coagulatie parameters o Factor II o Factor VIII o Antitrombin | — |
Countries
Netherlands
Outcome results
None listed