arteriosclerosis atherosclerosis hardening of the arteries
Conditions
Interventions
All subjects will receive in a random order three meals: a meal with
homogenized whole milk, a meal with unhomogenized whole milk, and a meal with
skimmed milk with butter. The amounts of energy wil
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy men will be included. The inclusion criteria are - aged between 18 and 70 years - Quetelet index between 25 - 30 kg/m2 - mean serum triacylglycerol (
Exclusion criteria
Exclusion criteria: - women - aged 70 years - Quetelet index below 25 or above 30 kg/m2 - mean serum triacylglycerol (>=1.7 mmol/L) - indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus - lactose intolerant - current smoker - familial hypercholesterolemia - abuse of drugs - more than 21 alcoholic consumptions per week - unstable body weight (weight gain or loss > 3 kg in the past three months) - use of medication or a diet known to affect serum lipid or glucose metabolism - severe medical conditions that might interfere with the study, such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases and rheumatoid arthritis. - active cardiovascular disease like congestive heart failure or recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter are differences in the iAUC of serum triacylglycerol curves. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are differences in changes in plasma markers for glucose metabolism, inflammatory markers, and endothelial activity, changes in microcirculation based on retinal imaging and changes in macrocirculation based on PWV measurement. | — |
Countries
Netherlands
Outcome results
None listed