De verslavende eigenschappen van nicotine en de mogelijke behandeling dmv vaccinatie worden onderzocht, rookgedrag levert een verhoogd risico op een scala van medische aandoeningen, preventie of vroege behandeling is daardoor gewenst. nicotine addiction smoking
Conditions
Interventions
The group will be randomised in two subgroups, one will recieve 5 injections
with NicVAX, 4 weeks inbetween in the alternating deltoid muscle, the other
group will recieve placebo vaccinations.
On
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male,18-45 years of age, smoking at least 10 cigarettes/day the last year, right handed in general good health
Exclusion criteria
Exclusion criteria: Vaccination exclusion: allergic reactions, known immunodeficiencies, current or recent malignancy or chemotherapy fMRI exclusion: claustrofobia, metalic implants etc, use of psychofarmaca nicotine challenge: buccumucosal leasions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation between nicotine specific antibody and 1) the BOLD response during resting state, during the smoking-cue reactivity paradigm and during task performance; in regions of interest associated with the specific tasks; 2) the number of correct response and the reaction time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between nicotine specific antibody and subjective signs of nicotine addiction, measured with several questionnaires | — |
Countries
Netherlands
Outcome results
None listed