high risk for cardovascular diseases and diabetes mellitus Metabolic Syndrome
Conditions
Interventions
A Paleolithic diet for 14 days compared to an isocaloric diet consistent with
*Guidelines for a healthy diet 2006* of the Health Council of the Netherlands.
Sponsors
Louis Bolk Instituut
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Written informed consent -Age >= 18 and = 102 cm (male) and >= 88 cm (female) -Elevated triglycerides: TG >= 1.7 mmol/L -Reduced HDL cholesterol: HDL-C = 130/85 mmHg or medication for hypertension -Elevated fasting plasma glucose >= 5.6 mmol/L •Willingness to not consume alcohol during the intervention
Exclusion criteria
Exclusion criteria: -Diabetes mellitus type 2, cardiovascular diseases, stroke, cancer and psychological disorders -Systolic bloodpressure > 180 mmHg -Smoking (within a month prior to the study) -10 years mortality risk caused by cardiovascular disease > 10 % according to NHG-standard M84 Cardiovascular Risk Management (November 2006) -Concomitant pharmacological treatment with hypoglycaemic agents, insulin, warfarin or oral steroids -Participation in an other clinical trial at the same time or within the previous month prior to enrolment into this study -Pregnancy or lactation -Recent blood donation (within the last 2 months) -Severe internal or systemic disease (e.g. cardiac, hepatic, renal diseases). -Non -omnivore (e.g. vegan, vegetarian) -Unwillingness to eat fish
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameters of the MetS: •Oral glucose tolerance •Fasting insulin, glucose, systolic /diastolic blood pressure, serum total-, LDL- and HDL-cholesterol and triglycerides . | — |
Secondary
| Measure | Time frame |
|---|---|
| •Intestinal permeability •HOMA •Body weight and waist circumference •Inflammation parameters •Salitivary cortisol | — |
Countries
Netherlands
Outcome results
None listed