Determination of dihydropyrimidine dehydrogenase and thymidylate synthase activity in human peripheral blood mononuclear cells in healthy volunteers.

Determination of dihydropyrimidine dehydrogenase and thymidylate synthase activity in human peripheral blood mononuclear cells in healthy volunteers. - DPD and TS enzyme activity determination

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36760

Enrollment

Registered

2010-03-10

Start date

2010-03-29

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DPD and TS enzyme activity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Healthy volunteer; not known with cancer or current treatment for cancer, and without any surgical operation in the past 6 months 2. Age > 18 years 3. Able and willing to give written informed consent 4. Able and willing to undergo blood sampling for DPD enzyme activity analysis 5. Able and willing to undergo blood sampling for pharmacogenetic analysis

Exclusion criteria

Exclusion criteria: 1. Any treatment with investigational drugs within 30 days before the start of the study 2. History of cancer 3. Any treatment with anti-cancer drugs 4. Legal incapacity 5. Any condition that may interfere with the study protocol

Design outcomes

Primary

Measure	Time frame
ranges of and mean DPD resp. TS enzyme activity in healthy volunteers	—

Secondary

Measure	Time frame
Correlation of DPD and TS enzyme activity with DPD and TS gene expression and observed polymorphisms in DPYD resp. TYMS.	—

Countries

Netherlands

Outcome results