hypertension in pregnancy toxemia of pregnancy
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Pre-eclampsia, defined as 1) hypertension (>140/90 mmHg) on at least two separate occasions and 2) proteinuria (>300 mg/24 hrs) Pregnancy 20 weeks or more gestation Age 18-42 years Able to provide written informed consent
Exclusion criteria
Exclusion criteria: Any chronic inflammatory condition Primary renal disease Diabetes mellitus or gravidarum Smoking Anti-phospholipid antibody syndrome Eclampsia (e.g. convulsions, restlessness, somnolence, hyperreflexia) Need for intravenous BP lowering therapy or magnesiumsulphate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in glycocalyx volume between patients with pre-eclampsia and healthy pregnant controls as indirectly estimated by SDF imaging and measurement of glycocalyx constituents and enzymes in plasma at admission to the hospital and 3 months after delivery of the baby. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Association between severity of pre-eclampsia and glyocalyx perturbation as assessed by SDF imaging, levels of glycocalyx constituents and enzyme activity. - Association between glycocalyx perturbation in patients with pre-eclampsia and coagulation abnormalities. - Association between glycocalyx perturbation and levels of anti-angiogenic factors (sFLT-1 and sEndoglin) in patients with pre-eclampsia. | — |
Countries
Netherlands
Outcome results
None listed