RA Reumatoid Arthritis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All subjects: 18-85 years Individuals with pre-clinical arthritis (n 25 IU/ml, or IgM-RF of > 49 IU/ml. RA patients with active disease (n
Exclusion criteria
Exclusion criteria: All subjects * Cardiovascular disease; such as ischaemic heart disease, cardiomyopathy, cardiac arrhythmia, cerebrovascular events, hypertension * Neurological disorders, such as parkinsonism and multiple sclerosis * Diabetes Mellitus and Hypercholesterolemia * Medication influencing blood pressure or heart rate * Pregnancy * Nicotine use (smoking , nicotinegum or patch) Individuals with Pre-clinical Arthritis * Clinically evident arthritis * Use of Disease Modifying Anti-Rheumatic Drugs (DMARDs) * Systemic or intra-articular corticosteroid injection less then 28 days before enrolment Active RA patients * Use of TNF-blockers or anti-IL6 treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate variability in subjects with pre-clinical arthritis, patients with active RA and healthy subjects. Heart rate variability is a reflection of the autonomic nervous system and these results will be related to clinical presentation and physical examination of the subjects, furthermore they will be compared with inflammation parameters in the blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Next to the primary outcome, the 24 hour heart rate variability will be analysed for day and night differences. We will evaluate if the normal day/night HRV found in healthy subjects, is also present in RA patients. | — |
Countries
Netherlands
Outcome results
None listed