Preservation of microcirculatory perfusion after pulsatile cardiopulmonary bypass: the role of prothrombogenic processes and the endothelium.

Preservation of microcirculatory perfusion after pulsatile cardiopulmonary bypass: the role of prothrombogenic processes and the endothelium. - PULSATILE II

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36700

Enrollment

Registered

2011-03-14

Start date

2011-06-28

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bypass operation cardiac surgery

Interventions

The intervention consists of the application of one type of cardiopulmonary bypass (conventional or pulsatile CPB). All interventions are part of standard clinical care.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing coronary artery bypass graft (CABG) surgery Age 40-85 years Informed consent

Exclusion criteria

Exclusion criteria: Re-operations and emergency operations Patients with insulin-dependent diabetes mellitus Patients with a body mass index (BMI) > 35 kg/m² Patients with anemia (Hb

Design outcomes

Primary

Measure	Time frame
Change in microcirculatory perfusion, sublingual erythrocyte velocity, capillary diameter and capillary density.	—

Secondary

Measure	Time frame
Change in fibrin network formation, platelet aggregation, endothelial function, fybrinolysis and red blood cell deformability.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)