heart failure
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group 1: Patients with exertional dyspnea thought to be caused by HFPEF - Exertional dyspnea (NYHA functional class 2 or higher) - All common causes of exertional dyspnea are excluded such as pulmonary disease, anaemia, myocardial ischemia, pulmonary hypertension, systolic heart failure, severe valvular disease, according to the diagnostic algorithm in figure 2. Group 2: Patients suffering from hypertension - Patient suffering from pulmonary hypertension, scheduled for right-sided heart catheterisation
Exclusion criteria
Exclusion criteria: -Inability to give informed consent or refusal to participate in the study -Acute or chronic physical impairment (other than dyspnea) limiting the ability to comply with study requirements -Age 32 kg/m2 -Use of oral anticoagulation -History of stress-induced syncope or ventricular tachycardia during exercise -Significantly impaired left ventricular ejection fraction, i.e. LVEF 2 or signs of silent ischemia during stress-testing (ergospirometry) -Impaired pulmonary function assessed by spirometry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are invasively measured cardiac and pulmonary hemodynamics by right heart catheterisation in rest and during exercise, compared between the three study groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are 1) non-invasively measured hemodymics by echocardiographic and Nexfin monitoring compared to invasively measured hemodynamics at rest and during exercise, 2) venous and arterial concentrations of NO-metabolites, endothelin-1, E-selectins, ANP, BNP, AT-II, thrombomodulin and von Willebrand factor at rest and during exercise and 3) heart rate variability between the three study groups. | — |
Countries
Netherlands
Outcome results
None listed