distribution of ventilation Lung mechanics work of breathing
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: *mechanical ventilation for at least 24hours *weight> 3kg *able to initiate and maintain spontaneous breathing *stable ventilator settings, defined by the absence of need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2
Exclusion criteria
Exclusion criteria: *mechanical ventilation less than 24hours *unstable ventilator settings, defined by the need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2 > 0.6 within 6 hours prior to enrolment *unstable haemodynamics, defined by the need for increase in vaso-ative drugs and/or fluid challenges within 6 hours prior to enrolment *leakage around the endotracheal tube > 5% *admitted to the neonatal intensive care unit *premature birth with gestational age corrected for age less than 40 weeks *congenital or acquired neuromuscular disorders *congenital or acquired central nervous system disorders with depressed respiratory drive *congenital or acquired damage to the phrenic nerve *congenital or acquired paralysis of the diaphragm *use of neuromuscular blockade prior to enrolment *uncorrected congenital heart disorder *chronic lung disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Global lung aeration before and during spontaneous breathing during mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Work of breathing at various pressure support levels during spontaneous breathing: -Area of the oesophageal pressure - volume curve -Oesophageal pressure * time product -Oesophageal pressure * rate product Patient comfort at various pressure support levels during spontaneous breathing | — |
Countries
Netherlands
Outcome results
None listed