requirement of one of the essential amino acids threonine requirement
Conditions
Interventions
The subjects will adapt for 24 hours to the study formula. At the study day,
subjects will receive a primed (15 µmol/(kg) continuous (10 µmol/(kg•h))
enteral infusion of [13C]bicarbonate for 2.5 h t
Cherwood
Medical, Tullamore, Ireland) will be placed 1 to 1.5 cm into the nasopharynx
and end-tidal breath will be taken slowly with a syringe connected at the end.
Baseline samples will be obtaine
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Preterm infants with a gestational age of 30-35 weeks and a birth weight of less than 2200 grams Fully enterally fed prematures with a postnatal age 10 g/kg/d in preceding 5 days
Exclusion criteria
Exclusion criteria: Congenital anomalies Sepsis Gastro-intestinal pathology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will test the requirement of threonine by breakpoint estimation. This will be determined by applying a two-phase linear regression model. | — |
Countries
Netherlands
Outcome results
None listed