increased phytosterol concentrations
Conditions
Interventions
During each test period, the volunteers will consume 20 gram of a plant
sterol-enriched margarine (providing daily 3.0 gram of plant sterols), a plant
stanol-enriched margarine (providing daily 3.0
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: aged between 18 and 70 years Body Mass Index (BMI) between 20-30 kg/m2 mean serum total cholesterol
Exclusion criteria
Exclusion criteria: - unstable body weight (weight gain or loss > 3 kg in the past two months) - active cardiovascular diseases like congestive heart failure or recent (21 units per week) - not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in sterol or stanol esters 4 weeks before the start of the study (wash-in period) - use of an investigational product within another biomedical study within the previous month - pregnant or breast-feeding women - not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study - current smoker - anemia. with a Hb-level below 7.5 mmol/L for men and below 7.0 mmol/L for women, as indicated by the blood bank of Maastricht
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum / plasma concentrations of plant sterols and oxyphytosterols, | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations of lipoproteins, glucose, insulin, and markers reflecting low-grade systemic inflammation and endothelial dysfunction. | — |
Countries
Netherlands
Outcome results
None listed